In silico designing of DASM with Pyrazofurin, a possible drug candidate for Anthrax

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Year 2017 Vol 6 Issue 4
Document Type : ORIGINAL ARTICLE
¹Prashantha Karunakar, ²K V Shiva Kumar, ³C Sunil Kumar, ⁴V Krishna Murthy, ⁵C R Girija
¹Department of Biotechnology, PES University, Banashankari III Stage, Bangalore – 560085, Karnataka India.
²Department of Biotechnology, PES University, Banashankari III Stage, Bangalore – 560085, Karnataka India.
³Department of Biotechnology, PES University, Banashankari III Stage, Bangalore – 560085, Karnataka India.
⁴Department of Biotechnology, PES University, Banashankari III Stage, Bangalore – 560085, Karnataka India.
⁵Department of Chemistry, Government Science College, Nrupatunga Road, Bangalore—560001, Karnataka India
Abstract
Bacillus anthracis is a notorious occupational zoonotic agent causing anthrax to veterinarians.
In this study, for the purpose of lead development, Dehydro Andrographolide Succinic acid Monoester (DASM) inhibitor of Furin was selected as a template.Anthrax infection is highly lethal in its most virulent form and produces a combination of three endotoxins namely Protective antigen, Lethal factor and Edema factor.
Furin is involved in other diseases, DASM was modified by adding anti-cancer, anti-inflammatory, anti-tuberculosis and anti-viral groups.

Keywords
Bacillus anthracis, Dehydro Andrographolide Succinic acid Monoester, Furin, Protective antigen, Lethal fator
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