An in silico based characterization and analysis of Human matrix metalloproteinases (MMPs)

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Year 2015 Vol 4 Issue 3
Document Type : Original article
¹Pritam Kumar Panda* ² Selvaa Kumar C* ³falcon ⁴c ⁵c
¹School of Biotechnology and Bioinformatics, D.Y. Patil University, CBD Belapur, Navi Mumbai-400614, India
²School of Biotechnology and Bioinformatics, D.Y. Patil University, CBD Belapur, Navi Mumbai-400614, India
³Hacked By
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Abstract
Potentially involved proteins which are implicated as a specific target for any diseased condition may implicate certain unusual features in several pathological conditions. Human Matrix metalloproteinase (MMP) family of endopeptidases is one such family responsible for many beneficial as well as several pathological critical diseases. With the advent of field of bioinformatics and computational efforts can aid researchers to comprehend their system of work

An insilico characterization of the MMP family has been carried out to analyze their primary, secondary, structural and functional perspective . The research has been focused on specific MMPs in which the further study was based on Mutational analysis confirming the pathogenicity of MMPs in cancer metastasis. The basic approach was to screen large protein families which plays dual role during normal and diseased conditions.
Thus it is hypothesized that cysteine rich and highly thermostable MMPs might be key players in diseased conditions. It can also be concluded that the disease responsive MMPs might be considered as promising targets for treatment of cancer.
Keywords
MMP Physio-chemical analysis MSA SOPMA I-Mutant Polyphen
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