Exploring polyene antifungal Streptomyces nodosus for yield improvement of Amphotericin B

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Year 2013 Vol 2 Issue 2
Document Type : Short communication
¹Anitha Upadhyaya1* ², Nagasatya A2 ³Thajuddin N3 ⁴Paneerselvam A4
¹1Department of Microbiology, J J College of Arts and Science, Pudukkottai,TN, India
² 2Department of Zoology, Govt Arts College for women, Pudukkottai, Tamilnadu. India, 3D
³Department of Microbiology, Bharathidasan University, Tiruchirapalli-24, Tamilnadu
⁴4 P.G. and Research Department of Botany, Microbiology, A.V.V.M. Sri Pushpam College,(Automomous), Poondi, Tamilnadu, India
Abstract
: Protein inhibitors are the common additives employed in the production of Amphotericin B to suppress the production of Amphotericin A, a less potent drug. Use of protein synthesis inhibitors for the production of Amphotericin B inhibiting Amphotericin A have been predominantly employed in the pharmaceutical industries. Although it reduces the production of Amphotericin A, it also yields lesser amounts of Amphotericin


This clearly indicates that addition of polyene antibiotics act synergistically in Amphotericin B production
Keywords
Amphotericin B, polyene, antifungal, Nystatin
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